Electronic Detection

Ohmx biochips consist of an array of electronically active gold electrodes, used to simultaneously detect different biomarkers within a single sample (see figure below). Ohmx’s detection technology relies on changes of energy levels  measured at the individual electrodes in the array, which occur in the presence of  target biomarkers and other clinical indicators.  Ohmx has developed multiple proprietary assays having configurations dependent upon the analyte of interest.

Each electrode of the sensor’s microarray is individually spotted and uniquely modified to include  a mixed monolayer of  the sensing element that has the following key features:       

- A molecular wire that anchors it to the electrode and is used to shuttle electrons       

- A redox active metal sensing atom, whose energy level is measured after sample addition       

- A capture probe specific for each target, which in different configurations include high affinity  capture ligands, such as peptides or aptamers for binding assays, peptides with scissile bonds  recognizable specifically by different target proteases, or a self-immolative  group that works in conjunction with standard immunoassay approaches for high sensitivity assays.

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